Herbal treatment of gastric reflux with
Anti-Reflux-B Syrup
Elimination of symptoms of return of acidic contents of stomach to esophagus
Elimination of symptoms of return of acidic contents of stomach to esophagus
Consists of aloe vera leaf gel
Herbal treatment of gastric reflux with
Elimination of symptoms of return of acidic contents of stomach to esophagus
120 ml syrup with spoon and brochure in a cardboard box
Standardized based on the presence of 2.5 mg of glucomannan per 5 ml of syrup
Aloe Vera leaf gel
Do not take in case of known allergy to aloe vera or pregnancy.
Rarely, dermatitis has been reported after oral and topical use of aloe vera gel.
The change in urine color to yellow, brown, or red is not clinically significant and may be due to the presence of anthraquinone metabolites that were introduced during gel extraction.
In a case study in vivo, a decrease in serum levels of thyroid hormones (T3, T4) was reported by aloe vera.
1-2 tablespoons of jam (5-10 ml) daily before breakfast and at bedtime
GERD disease; Due to the inadequacy of the lower esophageal sphincter (LES), the formation and return of acidic stomach contents to the esophagus causes damage to the esophageal mucosa and symptoms such as heartburn, dry cough, bad breath, sleep disturbances, bleeding and esophageal ulcers. .
Lifestyle changes are supported as one of the treatments for GERD, which generally falls into three groups:
Avoid foods that lower LES pressure and cause reflux, such as fatty foods, alcohol, mint, tomato foods, and possibly coffee and tea.
Avoid acidic foods that inherently irritate the mucous membranes.
Performing behaviors that minimize reflux and heartburn.
The predominant pharmacological approach in GERD is the use of inhibitors of gastric acid secretion, and much information supports the effectiveness of this approach. Reducing the acidity of gastric juice pharmacologically does not prevent reflux but improves the symptoms of reflux and allows the esophagus to repair. Proton pump inhibitors (PPIs) are more effective than histamine H2RAs receptor antagonists, both of which are superior to placebo. Side effects of treatment with PPIs are usually minimal, however, B12 and iron absorption may be compromised and the patient may be prone to intestinal infections, especially colostridium-induced colitis.
Aloe vera gel (yellow aloe) has various compounds to heal wounds, repair heat damage and burns, and relieve inflammation. One of the therapeutic uses of aloe vera gel is its use in the disease of returning acidic contents of the stomach to the esophagus.
The mechanisms of action of aloe vera gel are unknown. However, in vivo, aloe vera gel and its compounds modify the immune inhibition caused by ultraviolet radiation. Also in vitro, some components of aloe and its total gel have antioxidant effects. Aseman, which is one of the main components of aloe vera gel, has immune stimulant effects.
Aloe vera is a popular medicine for treating a wide range of gastrointestinal disorders. Aloe vera has been shown to improve various gastrointestinal function parameters in healthy individuals, including gastrointestinal pH.
Following an initial report on the effect of aloe vera gel in ulcerative therapy, many studies have been performed on animal models as well as on humans. Yusuf et al. Report that aloe vera inhibits gastric acid secretion.
Also, the aloctin A in aloe reduces the secretion of acid and pepsin in rats whose pylorus is surgically closed and prevents indomethacin from developing gastric ulcers.
Another study showed that aloe vera reduced leukocyte adhesion and αTNF- levels, increased interleukin-10, and thus accelerated gastric ulcer healing. Also an emulsion prepared by mixing the juice and gel of this plant with mineral oil; Used to treat gastric ulcers in patients. The anti-ulcer effect of aloe vera seems to be due to its anti-inflammatory, cytoprotective, healing and mucosal stimulation effects.
Because according to previous studies, aloe vera has a good ability to reduce the secretion of acid and pepsin, and given the key role of these two factors in damage to the esophagus; This plant has good potential for treating GERD. On the other hand, several studies have proven the anti-inflammatory effect and wound healing effect for aloe vera, and if GERD is associated with injury and inflammation; Aloe vera is expected to have beneficial effects.
Diabetes mellitus alters acid secretion and increases the risk of stomach ulcers. In one study, in order to investigate the effect of diabetes mellitus on wound-causing parameters and to determine the effect of treatment with raw aloe vera gel on it, 20 male albino Wistar rats weighing 180-180 g were randomly divided into one of 4 groups; Control, untreated diabetic (DM), diabetic treated with 0.4 ml / 100g crude aloe vera gel (DMT) and control treated with 0.4 ml / 100g crude aloe vera gel (CT). Rats of all groups had free access to water and food. At the end of 21 days of aloe administration, gastric ulcer was formed using standard methods and the output score of gastric acid, gastric mucus and gastric ulcer were determined. The results of this study showed that raw aloe vera gel neutralizes the ulcerative effect of diabetes mellitus by reducing gastric acid secretion and increasing mucus secretion.
According to a randomized placebo-controlled study of 58 patients with Irritable Bowel Syndrome (IBS) with diarrhea prevailing, 35% of aloe vera recipients responded in the first month (compared with 22% in the placebo group). In general, patients using aloe vera had a significantly higher response rate than placebo (43% vs. 22%).
In a randomized, double-blind, placebo-controlled clinical trial, the efficacy and safety of aloe vera gel (100 ml twice daily for 4 weeks) in patients with ulcerative colitis were evaluated. Aloe vera improved clinical remission in 30% of patients (compared with 7% in the placebo group) and improved symptoms in 37% of patients (compared with 7% in the placebo group). Simple Clinical Colitis Activity Index and histological score in patients receiving aloe vera significantly decreased but did not change in the placebo group.
In a randomized controlled clinical trial, 79 patients aged 18 to 65 years with gastroesophageal reflux disease were evaluated for 4 weeks in the anti-reflux syrup-free group of Barige Essential Oil Company (containing aloe vera), the omeprazole capsule group or the ranitidine tablet group. . Patients received 10 ml of anti-reflux syrup or 20 mg capsules of omeprazole once daily on an empty stomach or twice daily in the morning and half an hour before bedtime at a dose of 150 mg of ranitidine.
Patients were evaluated for symptoms of heartburn, heartburn, dysphagia, bloating, sore throat, nausea, vomiting, and return of gastric contents to the esophagus two weeks before and four weeks after treatment. After 2 and 4 weeks of treatment, the severity of GERD symptoms was assessed. The prevalence of GERD symptoms at the beginning of the study was the same in all three groups (p> 0.05). Compared to the beginning of treatment, in the aloe vera syrup group, the prevalence of all GERD symptoms decreased in weeks 2 and 4 of treatment, and from week 2 to 4 of the trial, heartburn, bloating, and belching improved more. Compared to the beginning of treatment, in the omeprazole group, the prevalence of all GERD symptoms decreased in weeks 2 and 4 of treatment, and compared to the second week of treatment, in week 4 of the trial, heartburn, bloating, belching and return of acidic stomach contents to esophagus were further reduced. . Compared with the start of the study, in the 2nd week of treatment, in the ranitidine group, the prevalence of heartburn, bloating, belching, nausea, vomiting and return of acidic contents of the stomach to the esophagus significantly decreased and compared with the start of treatment and the second week, In the fourth week, the prevalence of all symptoms except bloating decreased significantly. The results of this study showed that the use of aloe vera syrup is safe, is effective in reducing the symptoms of GERD, and is well tolerated by consumers without side effects that lead to non-drug use.
Barij Essential Pharmaceutical Company is a manufacturer of herbal medicines and the first pharmaceutical knowledge-based company in the country. This company was established in 1992 with the aim of improving and promoting the health of the community.
Factory: Kashan Mashhad Ardehal | Phone: 4002 (086)
Tehran Office: Marzdaran St., between Ariafar and Sarsabz, No. 78
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