Herbal anti-sputum and cough syrup
Bronco Barij Syrup
Anti-sputum and cough
Anti-sputum and cough
Composed of Zataria multiflora extract and marshmallow extract
3 times a day, one tablespoon each time (5 ml)
Zataria multiflora
Althaea officinalis
Breastfeeding is contraindicated during pregnancy and in children under 4 years of age
Allergic reactions (contact dermatitis) have been observed in sensitive individuals, irritation of the mucous membranes, kidney problems with prolonged consumption and in excess of the recommended amount.
Syrup 120 ml in a cardboard box
Standardized based on the presence of 2.56-3.56 mg thymol and 245.229-225 mg amino acids per 5 ml of syrup
1. Thyme Shirazi:
Commission E has approved the use of thyme (Thyme) for the treatment of cough and bronchitis. Thymol and carvacrol have been shown to have a wide range of effects against bacteria involved in upper respiratory tract infections. Thymol and carvacrol are believed to exert their antibacterial activity by forming complexes with bacterial membrane proteins. A synergistic effect has also been identified for the combination of thymol and crocrocol. Carvacrol is the main component of thyme essential oil, which has been proven to have antibacterial and antifungal effects on various microorganisms. Adequate doses of thymol and carvacrol have also been shown to have a tracheal relaxation effect.
Thyme essential oil is effective on pathogenic bacteria, especially Staphylococcus aureus (S. aureus). Thyme thyme has always been considered in relieving the symptoms of cough and colds of the upper respiratory tract as well as as an expectorant with antispasmodic effect and is used in the treatment of bronchitis and spasmodic cough in adults and in pertussis in children. Various trials have confirmed the effect of thyme on productive cough.
In a randomized, uninformed bilateral study, 60 patients with whooping cough received thyme or bromhexine syrup for a period of 5 days. According to the patient’s symptoms, there was no significant difference between the two groups, and both groups received the same benefit from taking the drug. Significant non-statistical improvement was observed in the recovery rate of non-smokers compared to smokers in both groups.
Also, in a randomized controlled double-blind clinical trial to evaluate the effects of thyme and fennel essential oil in the treatment of cough, 119 patients with acute cough; Three times a day, each time 20 drops of sweet fennel essential oil and thyme or clobutinol drops or placebo were used for 3 days. At the end of this period, complete recovery was reported in the group using drops containing sweet fennel and thyme essential oil and clobutinol drops, 50% and in the placebo group 9.1%. The effectiveness of drops containing sweet fennel and thyme essential oil, clobutinol and placebo drops in patients with sputum cough 66.7%, 55% and 14.3% and in patients with dry cough 56.5%, 55% and 20, respectively. % reported. In the improvement of cough, a significant difference was observed between drops containing sweet fennel and thyme essential oil and clobutinol drops with placebo (p <0.01). But there was no significant difference between drops containing sweet fennel and thyme essential oil and clobutinol drops (p> 0.4)
۲. Final:
Alfalfa leaf has been approved by Commission E for the treatment of irritations of the oral and pharyngeal mucosa with dry cough. Marshmallow is also used to treat inflammation of the gastrointestinal tract and respiratory tract, irritating cough and bronchitis. In animals, the antitussive effect of whole extract and marshmallow root polysaccharides was compared with non-narcotic drugs that suppress cough. Based on the results of this study, administration of polysaccharides caused a statistically significant reduction in the number of coughs and inhibition of cough reflex. Have been polysaccharides.
In vitro and in vivo, rhamnogalacturonan isolated from the root of marshmallow has shown various biological effects on the cough reflex and airway smooth muscle reactivity induced by citric acid. It is dose-dependent and has a cough suppressant effect comparable to codeine (a drug agonist). However, in vitro and in vivo, airway smooth muscle reactivity was not significantly affected by rhamnogalacturonone, so the bronchodilator effect was not involved in cough suppression. In addition, activation of K + ATP ion channels had no effect on the mechanism of antitussive effect. The mechanism of the cough suppressant effect of rhamnogalacturonan isolated from marshmallow root seems to be related to the function of 5-HT2 serotonergic receptors.
3. Thyme Shirazi and Khatami:
In an uninformed randomized clinical trial, 157 patients aged 10 to 85 years with acute cough received 5 ml of bronchodilator barrage syrup (n = 78) or 5 ml of dextromethorphan syrup (n = 79) every 8 hours for 4 days. 24, 48 and 96 hours after the start of treatment, clinical signs were recorded in the questionnaire. In each case, the level of recovery was assessed as complete recovery (complete cessation of cough), partial recovery (patient satisfaction with cough reduction or reduction of cough duration by half) or no improvement (no change in cough intensity). Also, the severity of cough was determined according to VAS (Visual Analogue scale) scoring in each visit, so that the line numbering was done from zero to 10 and zero (without cough) and score 10 (debilitating cough) were described.
According to the results of this study; After 96 hours, 50% of patients with cough who used syrup containing thyme extract and marshmallow completely recovered. In dextromethorphan group, this number was 49.3% and no significant relationship was observed between the type of drug used and the rate of improvement (P = 0.94). At the beginning of the study, the mean VAS score in the syrup group containing Zataria multiflora extract was 6.7 and in the dextromethorphan group was 6.8. At 24, 48 and 96 hours after the start of the study, this number was 4.4, 3.3 and 2.67 in the syrup group containing thyme and marshmallow extract, respectively, and in the dextromethorphan group was 4.49, 3.35 and 4, respectively. / 2 was obtained. Significant efficacy was observed for both drugs in all stages of treatment (P <0.001). Also, the mean decrease in VAS score in syrup users containing Zataria multiflora and marshmallow extract at different times was 2.3, 3.26 and 3.85, respectively, and in the dextromethorphan group were 2.3, 3.4 and 4.1, respectively, but there was a significant difference. No cough was observed between the two drugs (P> 0.06)
Barij Essential Pharmaceutical Company is a manufacturer of herbal medicines and the first pharmaceutical knowledge-based company in the country. This company was established in 1992 with the aim of improving and promoting the health of the community.
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