Herbal soft capsules
Phenylene barij
Increased breast milk
Relieve menstrual cramps
Increased breast milk
Consists of sweet fennel essential oil
30 mg soft capsule
Standardized based on the presence of 27-21 mg of anethole in each soft capsule
Sweet fennel essential oil (Foeniculum vulgare)
There is a possibility of increased bleeding during menstruation.
It has estrogenic effects, has a hepatic metabolism, and its metabolites are excreted in the urine.
Do not take this medicine if you have a history of allergies to fennel or any of its components, during pregnancy, in patients with allergic asthma, seizures, liver disease or cancer.
Take 1 every 4 hours
Painful menstruation (dysmenorrhea) is one of the most common disorders in women. More than 50% of girls have mild pain during menstruation, but 10% need absolute rest for 1-3 days a month. Painful menstruation has adverse effects on social relationships, loss of useful working hours for women, absence of schoolgirls from school, and great economic losses. Painful menstruation is divided into two types, primary and secondary, in the primary type of which there is no detectable pelvic disease.
In traditional Iranian medicine, fennel has been used as an anti-flatulence, diuretic, urinary tract stone repellent and milk enhancer.
To investigate the pharmacological effects of fennel essential oil on isolated uterine contractions in rats and to calculate LD50 in rats; Oxytocin (0.1, 1, 10 mu / ml) and prostaglandin E2 (5. 10-5 M) were used to induce muscle contraction. Different doses of fennel essential oil significantly reduced the contractions induced by oxytocin and prostaglandin E2 (25.50 µ g / ml for oxytocin and 10.25 / g / ml for prostaglandin E2, respectively). Fennel essential oil also reduced the frequency of contractions induced by prostaglandin E2 (not the frequency of contractions induced by oxytocin). In this study, LD50 calculated by moving average method was equal to 1326 mg / kg. The following are the results of several clinical trials related to the effect of fennel essential oil in relieving menstrual pain:
1- In order to compare the effect of sweet fennel essential oil with mefenamic acid in the treatment of early painful menstruation, 30 women aged 15 to 24 years with moderate to severe primary dysmenorrhea were studied in 3 menstrual periods. In the first period, no medication was prescribed (control period), in the second period, patients were treated with mefenamic acid (250 mg every 6 hours) and in the third period, they were treated with 2% fennel essential oil (25 drops every 4 hours). The results of this study showed that compared to the control period, both drugs effectively relieved menstrual pain (P <0.001). The mean onset time was 67.5 ۶ 46 برای 46 minutes for mefenamic acid and 75 ± 48.9 minutes for fennel, which was not statistically significant (P = 0.57). On the second and third days of menstruation, mefenamic acid had a stronger effect than fennel (P <0.05). However, on other menstrual days, there was no statistically significant difference between the two drugs. No side effects from mefenamic acid were reported. The researchers concluded that fennel could be used as a safe and effective herbal medicine for early painful menstruation.
2- During a double-blind, placebo-controlled crossover trial in 60 single female students living in the dormitory of the University of Tehran in the age range of 17-25 years who had primary dysmenorrhea and the severity of their dysmenorrhea according to Andersch & Milsom oral grading system in grade 2 or 3 And had pain in all or most periods after examination and ultrasound and confirmation of primary dysmenorrhea; They were randomly divided into 6 groups (resulting from 6 combinations of letters A, B, C) and each person was examined for 3 periods. In this study, drops containing 1% and 2% fennel essential oil were used so that the patient would want 40 drops as soon as the pain started and repeat it every 4 hours if necessary. If the pain did not decrease within 2 hours after taking the test drug and the pain was unbearable, the patient was allowed to take his usual painkiller and write it down in the appropriate form.
Based on the results of this study; Compared with placebo for the pain intensity variable, a statistically significant difference was observed between the groups receiving 1% and 2% essential oil drops (p <0.05). According to the results, the researchers concluded that fennel essential oil of 1% and 2% caused complete relief of menstrual pain in 52.8% and 67.4%, respectively, and partial and partial pain relief in 47.2% and 28.6%, respectively. % Of people who are almost comparable to the effects of nonsteroidal anti-inflammatory drugs (NSAIDs).
3. In order to compare the effect of ibuprofen and fennel essential oil on primary dysmenorrhea, in a clinical trial, 120 high school girls with moderate to severe dysmenorrhea were randomly selected from 4 high schools in different parts of Mashhad. They were monitored for one cycle (control cycle) and filled in the number one form. In the second and third cycles, half of the samples were given ibuprofen tablets (400 mg, orally every 4-8 hours as needed) and the other half were given a 2% essential oil drop (20-30 drops, taken orally every 4-4 hours according to research needs). They completed number two in these two cycles. Based on the results of data analysis of 100 people, 2% essential oil of fennel plant reduced the severity of dysmenorrhea (p <0.001) and duration of dysmenorrhea (p = 0.000) in the individual. Measures relieved dysmenorrhea. The need for additional analgesia was similar in the two groups (p = 0.148). Consumption of 2% fennel essential oil also reduced the mean duration of bleeding (p = 0.045). Bleeding rate before and after consumption of fennel essential oil was 2%, there was no significant difference (p = 0.308) and consumption of fennel essential oil did not change the rate of bleeding. There was a decrease in bleeding in the ibuprofen group (p = 0.038). Satisfaction with the use of drugs was not statistically significant and similar (P = NS). It is able to relieve primary dysmenorrhea and can be a good substitute for ibuprofen tablets, although the definitive mechanism of action of this plant is unknown.
4. In a prospective clinical trial, 60 students with a history of premenstrual syndrome (PMS) were selected and in 5 menstrual cycles (first cycle without drug use as control, second and third cycle with fennel drug and fourth and fifth cycle with chamomile drug) were investigated. After each cycle, the study group was assessed by filling out a questionnaire containing 16 signs of PMS and dysmenorrhea. Based on the results of this study; Significant reduction in the severity of symptoms between the control cycle (placebo) with the cycles of consumption of fennel and chamomile was observed only in the three symptoms of abdominal and pelvic pain, fatigue and lethargy, and depression or anger from the 16 symptoms in the questionnaire (p <0.05). In other cases, although the severity of symptoms was lower in the fennel and chamomile consumption cycles, the difference with the drug-free cycle was not significant. The researchers concluded that consumption of fennel and chamomile has a statistically significant effect on only 3 symptoms of PMS and dysmenorrhea, among which chamomile is more effective in abdominal and pelvic pain, depression and anger, and fennel is more effective in reducing fatigue and lethargy.
Fennel has also been used to treat amenorrhoea and increase milk production in breastfeeding mothers.
Barij Essential Pharmaceutical Company is a manufacturer of herbal medicines and the first pharmaceutical knowledge-based company in the country. This company was established in 1992 with the aim of improving and promoting the health of the community.
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