Elimination of urinary problems in prostate patients
Urtidin F.C Tablet
Fix urination problems in benign prostate enlargement
Consists of nettle root extract
Fix urination problems in benign prostate enlargement
Elimination of urinary problems in prostate patients
Fix urination problems in benign prostate enlargement
150 mg coated tablet, 10-digit blister with brochure in cardboard box
Standardized based on the presence of at least 22 mg of amino acids in terms of alanine in each tablet
Take one tablet 3 times a day after meals with some fluids. With the start of treatment, the therapeutic effects gradually appear. Due to the chronic nature of benign prostatic hyperplasia, it is necessary to continue taking the drug for a long time.
Nettle root extract
Mild gastrointestinal complaints may occur occasionally. Decreased urinary incontinence and rarely edema have been reported occasionally.
Overuse of orthidine with antidiabetic drugs and drugs that affect blood pressure can interfere.
Orthidine exacerbates the effects of central nervous system depressants.
Iron supplements should be taken 1-2 hours after taking ortidine.
Benign prostatic hyperplasia is the most common disease in older men with obstructive and irritative symptoms. 80-50% of men over the age of 50 suffer from BPH symptoms. Herbal drugs 1α and 5-alpha-reductase inhibitors are commonly used to improve the symptoms of patients with BPH. Herbal medicines are also very common in the treatment of this disease and nettle is one of the most famous plants in this regard.
Nettle root contains a mixture of water-soluble and alcohol-soluble compounds including lectins, phenols, sterols and lignins. The use of nettle root for complaints of irritated prostate and bladder has been approved by Commission E. According to the commission, nettle root reduces residual urine and increases urine flow. Nettle root products have been used to treat urinary disorders in stages I and (Alken, 1973) II or stages II and, Vahlensieck & Fabricius, 1996) III (Anonymous, 2003) Benign prostatic hyperplasia and relieve symptoms of enlarged prostate .
Pharmacological properties: In vitro tests
Reaction with Sex Hormone Binding Globulin (SHBG): Aqueous extract of nettle root in a dose-dependent manner inhibits its binding to prostate membrane receptors. Polar lignans, such as secoisolariciresinol, interfere with SHBG binding to steroids. The proposed mechanisms are:
1- Changing the blood level of free (active) steroid hormones by changing their location from SHBG binding sites 2- Preventing the prostate receptors from reacting with SHBG.
Reaction with aromatase enzyme: There is strong evidence that nettle extract is involved in the conversion of testosterone to estrogens. In vitro, ethanolic extract of nettle root inhibits the aromatization of androstenedione. The lipophilic components of the extract appear to be involved.
Reaction with 5α-reductase enzyme: Only large amounts of nettle root methanolic extract inhibit 5-alpha-reductase enzyme. Also, ether petroleum extract of nettle is very strong in inhibiting the enzyme 5 alpha-reductase, and athanolic and aqueous extracts are in the next degrees.
Anti-inflammatory effect: Inhibition of elastase in human leukocytes indicates anti-inflammatory effects. Ethanol extract of nettle root inhibited the elastase of bovine leukocytes. Methanolic extracts and polysaccharide compounds also inhibit nettle root bypass system.
Effect on prostate cell growth: Nettle root extract may suppress prostate cell growth and metabolism by reacting with steroid receptors on the prostate membrane. Steroid compounds in the crude extract of nettle root accelerate the movement of macrophages to the target site and contribute to the anti-inflammatory effects of the drug. Steroids also inhibit the activity of the enzyme Na + K + ATPase, thereby inhibiting the metabolism and growth of prostate cells.
Pharmacological properties: In vivo tests
Anti-inflammatory effect: The effect of oral extract of nettle root and root components (especially polysaccharides) on carrageenan-induced rat paw edema has been investigated and has shown a potential anti-inflammatory effect. However, it remains to be seen whether this effect is related to the anti-prostate effect of nettle root.
Effect on prostate cell growth: In dogs, treatment with nettle root extract for 100 days reduced prostate size and serum testosterone levels.
Reaction with 5α-reductase enzyme: Only large amounts of nettle root methanolic extract inhibit 5-alpha-reductase enzyme. Also, ether petroleum extract of nettle is very strong in inhibiting the enzyme 5 alpha-reductase, and athanolic and aqueous extracts are in the next degrees.
Anti-inflammatory effect: Inhibition of elastase in human leukocytes indicates anti-inflammatory effects. Ethanol extract of nettle root inhibited the elastase of bovine leukocytes. Methanolic extracts and polysaccharide compounds also inhibit nettle root bypass system.
Effect on prostate cell growth: Nettle root extract may suppress prostate cell growth and metabolism by reacting with steroid receptors on the prostate membrane. Steroid compounds Pharmacological studies in humans
Effect on sex hormones: in two uninformed two-way studies compared with placebo; Decreased SHBG was observed during treatment with nettle root extract (1200 mg / day). However, Fischer and Wilbert (1992) observed a 10% increase in testosterone, 5α-DHT and estradiol concentrations over a 7-month treatment period. In uncontrolled open studies, it has been found that more estradiol and estrone are involved in the mechanism of action of nettle root than testosterone and DHT
Effect on prostate cell growth: After treatment with nettle extract (600 mg per day), histological changes in prostate cells have been observed. After 9 weeks, the changes were reactive in the form of glandular cell death and inflammation (Streber, 1986). After 20 weeks of treatment at a dose of 1200 mg per day, changes have been reported in the form of decreased cellular metabolism (Ziegler, 1982). (4)
Clinical studies
The first case report on the beneficial effects of tea made from nettle root dates back to Rückle (1950), where the herbal diuretic effect was considered as a side effect. In 34 clinical trials, about 40,000 men with BPH were treated with various products containing nettle root.
In a placebo-controlled clinical trial in 79 patients with BPH, nettle root extract (600 mg daily from 5: 1 extract for 6-8 weeks) in all measured parameters (urine flow, urine volume and residual urine) It was superior to the placebo. In another similar trial, 50 patients with stage I and II benign prostatic hyperplasia treated with nettle root extract (600 mg daily from 5: 1 extract for 9 weeks) had a significant reduction in SHBG (p <0.0005) and Remarkable correction showed urine volume and maximum urine flow.
To determine the therapeutic effects of nettle on symptomatic improvement of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia, in an uninformed, randomized, cross-sectional, placebo-controlled trial of 620 patients for 6 months on the International Score of Prostate Symptoms (IPSS), maximum urinary flow rate (Qmax), residual urine volume after urination (PVR), serum specific prostate antigen (PSA), testosterone level and prostate size were studied. Accelerates macrophages to the target site and aids in the anti-inflammatory effects of the drug. Steroids also inhibit the activity of the enzyme Na + K + ATPase, thereby inhibiting the metabolism and growth of prostate cells.
Pharmacological properties: In vivo tests
Anti-inflammatory effect: The effect of oral extract of nettle root and root components (especially polysaccharides) on carrageenan-induced rat paw edema has been investigated and has shown a potential anti-inflammatory effect. However, it remains to be seen whether this effect is related to the anti-prostate effect of nettle root.
Effect on prostate cell growth: In dogs, treatment with nettle root extract for 100 days reduced prostate size and serum testosterone levels.
At the end of 6 months, patients who were taking placebo from the beginning used nettle and both groups continued treatment for 18 months. 558 patients completed the study. By intention-to-treat analysis at the end of the 6-month trial, compared with 16% of the placebo group; 81% of patients in the nettle group showed improvement in LUTS (P <0.001). In the case of IPSS and Qmax, the improvement with medication was higher than placebo. IPSS increased from 19.8 to 11.8 in the nettle group and from 17.2 to 17.7 in the placebo group (P = 0.002). The maximum flow rate improved in the placebo group by 3.4 ml / s and in the drug group by 8.8 ml / s (P <0.05). In the nettle group, PVR increased from the initial value of 73 ml to 36 ml (P <0.05), but no measurable change was observed in the placebo group. Serum PSA and testosterone levels remained unchanged in both groups. At the end of the study with rectal ultrasound (TRUS) in the nettle group, a relatively small decrease in prostate size was observed (from initial 40.1 cc to 36.3 cc, P <0.001) but in the placebo group there was no change in prostate volume. . At 18-month follow-up, only patients who continued treatment showed optimal values of treatment variables. No side effects were seen in nettle and placebo groups. The researchers concluded that nettle has beneficial effects in treating the symptoms of BPH.
In a double-blind clinical trial on 100 patients with BPH, patients were randomly assigned to the nettle (n = 50) or placebo (n = 50) group twice a day for 8 weeks, 2 300 mg nettle capsules or placebo at a time. To consume. The Demographic Information and International Prostate Symptoms Rating (IPSS) checklist was used to collect data. Based on the results of this study; Compared to placebo, nettle had a better effect on relieving the symptoms of BPH and no side effects were reported during the study.
In a double-blind clinical trial on 248 patients with symptoms of benign prostatic hyperplasia, these patients were randomly divided into 4 treatment groups: nettle group 3 g, nettle group 5 g, nettle group 7 g and prazosin group 1 mg. Before and 2 months after the start of the study; Symptoms, quality of life and specific prostate antigen (PSA) levels were measured. The results of this study showed a significant difference between the 4 groups in terms of the degree of clinical symptoms and quality of life of patients, but no significant difference was observed in terms of PSA. Sheffe post hoc comparison showed a significant improvement in the symptoms of patients in the nettle group 5 g / day and the nettle group 7 g / day. The results of this study showed that concomitant use of large amounts of nettle up to 7 g / day with prazosin, compared with prazosin alone, significantly improved the clinical symptoms of BPH.
Barij Essential Pharmaceutical Company is a manufacturer of herbal medicines and the first pharmaceutical knowledge-based company in the country. This company was established in 1992 with the aim of improving and promoting the health of the community.
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