Testosterone significantly increased prostate size ratio (p <0.05) and this increase was inhibited in rats fed 2 mg per 100 g body weight of pumpkin seed oil. The protective effect of pumpkin seed oil at a higher dose was significant (p <0.02). The researchers concluded that pumpkin seed oil inhibits testosterone-induced prostate hyperplasia, so it may be useful in the management of benign prostatic hyperplasia.

In the prostate, testosterone is converted to dihydrotestosterone in the presence of the enzyme 5 alpha-reductase, which is a stronger androgen and promotes prostate growth. Inhibition of dihydrotestosterone production or function can lead to inhibition of prostate growth. Studies have shown that the effect of pumpkin seed oil may be dependent on phytosterol compounds that interfere with the effect of dihydrotestosterone. Therefore, the effectiveness of pumpkin seed oil in BPH may be a direct effect on the size of the prostate gland and thus improve urinary function. In a randomized, double-blind, placebo-controlled clinical trial in 74 patients with benign prostatic hyperplasia and International Prostate Symptoms Score (IPSS) of more than 8, patients with sweet potato starch (Group A, placebo, 320 mg / day) over 12 months. ) Used pumpkin seed oil (group B, 320 mg per day), saw palm oil (group C, 320 mg per day) or pumpkin seed oil with saw palm oil (group D, 320 mg each).