The hepatoprotective effects of turmeric are mainly due to its antioxidant properties and its ability to reduce the production of proinflammatory cytokines. Turmeric and curcumin reverse bile duct hyperplasia, fat changes, and aflatoxin-induced necrosis. Sodium curcuminate shows its chlorotic effects by increasing bile secretion of bile salts, cholesterol and bilirubin and increasing bile solubility, so it may play a role in the prevention and treatment of gallstones. In one study, over 8 weeks, the hepatoprotective effects of turmeric rhizome ethanolic extract were studied in a thioacetamide-induced liver cirrhosis model in rats. The researchers concluded that the antioxidant and anti-inflammatory effects of ethanolic extract of turmeric rhizome could inhibit the progression of liver cirrhosis and maintain a normal liver position. Also, in the study of the effects of aqueous extract of turmeric rhizome in albino Swiss mice poisoned with CCl4, it was found that this extract has immunotherapeutic effects and can eliminate hepatotoxicity. In this study, turmeric rhizome extract reduced the levels of SGOT (AST), (ALT), SGPT and bilirubin. In the study of the effect of hydroalcoholic extract of dandelion root on rat liver fibrosis caused by CCl4, it was found that the therapeutic effect of this extract occurs by inactivating stellate cells and increasing the ability of the liver to regenerate. This study is a scientific document to prove the traditional use of dandelion root in liver disorders. In addition, in a study in mice, the hepatoprotective effect of dandelion leaf extract against acetaminophen-induced hepatotoxicity was determined due to the antioxidant properties of this extract.
The possible mechanism is the collection of reactive oxygen species (ROS) and activated nitrogen species that are associated with phenolic compounds in the extract. Another study found that dandelion root extract has a protective effect against alcohol-induced hepatotoxicity by increasing its antioxidant potential and reducing fat peroxidation.
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