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Medical texts and articles

Diarrheal diseases continue to be a major cause of disability and mortality worldwide. The first step in the treatment of diarrhea; Water supply and electrolytes and other measures to reduce the patient's symptoms such as nausea, vomiting, nausea, reduce the duration of the disease. A number of studies investigating the biological activity of plant-derived compounds by antispasmodic mechanisms, delaying intestinal transit, inhibiting intestinal motility, stimulating water uptake, or reducing electrolyte secretion; Has approved the use of anti-diarrheal herbs. Terpenes and terpenoids in savory essential oil have antispasmodic and antimicrobial effects, so it can also be used in microbial diarrhea.

Pharmacological studies

Comparison of the antispasmodic effect of savory essential oil with the effect of atropine and dicyclomine on contractions induced by KCl and acetylcholine in isolated rat ileum; Savory essential oil has been shown to have a relaxing effect on the smooth muscles of the rat ileum. Savory essential oil also inhibits diarrhea caused by castor oil in mice.

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Clinical trials

In a randomized controlled clinical trial, 71 patients with type I diarrhea ranged in age from 10 to 65 years; They were randomly divided into two groups of Lomex oral drops (n = 39) or placebo (n = 32) for a period of 3 days. The dose was 20 drops 3 times a day and patients were followed up 24, 48 and 72 hours after initial admission and statistical analysis was performed using SPSS software. Based on the results of this study; The mean time to stop diarrhea in the Lumex group was 17.3 hours and compared to the placebo group (35.3 hours) was significant (P = 0.013). 24 hours after the start of treatment, the frequency of heartburn in users of Lomex oral drops was 15.4% and in the placebo group was 40.6% (P = 0.16). The results of this study determined the value of Lomex oral drops in relieving the symptoms of diarrhea compared to placebo. According to research, Lumex is an effective and uncomplicated anti-diarrhea product.

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In another randomized controlled trial, 56 patients with type I diarrhea ranged in age from 10 to 65 years; They were randomly divided into two groups of Lumex soft capsules (29 patients) or placebo (27 patients) to take one soft capsule every 8 hours for 3 days. Patients were evaluated 24, 48 and 72 hours after the start of the study and the data were analyzed using t-test and Mann-Whitney test. Based on the results of this study; The improvement of diarrhea in the first 24 hours was 63% in the Lumex soft capsule group and 25.9% in the placebo group, and this difference was statistically significant (P = 0.013). This difference was also significant 48 and 72 hours after the onset of the disease (P <0.001 and P = 0.058, respectively). The frequency of heartburn 24 hours after the start of treatment was 35.7% in the Lumex soft capsule group and 68% in the placebo group (P = 0.058). In terms of the frequency of heartburn, 48 hours after the first visit, there was a significant difference between the group receiving Lumex soft capsule and the placebo group (P <0.001). Regarding the number of bowel movements, a significant difference was observed between the two groups 48 hours after referral (P <0.001) and in the Lumex soft capsule group it was significantly less. The mean time to stop diarrhea in Lumex soft capsule group was 25.7 ۶ 22.6 hours and in placebo group was 50.2 ۷ 25.7 hours and this difference was statistically significant (P <0.001); The cut-off time was 24.5 ‌‌ 21.5 hours in the placebo group and 10.8 ساعت 12.8 hours in the Lomex soft capsule group (P = 0.038). The results of this study determined the herbal medicinal value of Lomex soft capsule in relieving the symptoms of diarrhea compared to placebo.