Herbal syrup for the treatment of acute cough
Cafnolic Barrage
Treatment of acute cough (suitable for diabetics)
Treatment of acute cough
Consists of Thyme Shirazi, Khatami, Eshghe and Stevia
Herbal syrup for the treatment of acute cough
Treatment of acute cough (suitable for diabetics)
120 ml syrup in a box
Standardized based on the presence of at least 1.5 mg thymol and carvacrol and 2.5 mg hydroxide c per 5 ml of syrup
Allergic reactions (contact dermatitis) in sensitive individuals, irritation of the mucous membranes, as well as kidney problems with prolonged and excessive intake are recommended. In pregnancy, lactation and children under 4 years of age.
Zataria multiflora
Althaea officinalis
Hedera Helix
Stevia
To treat acute cough, take one tablespoon of jam (5 ml) each time 3 times a day. Taking more than the recommended daily allowance may have laxative effects.
The medical community faces cough as an unresolved and important clinical problem; Both because cough is a symptom of a wide range of diseases such as asthma, chronic obstructive pulmonary disease, and gastroesophageal reflux disease, and because it is a problem in patients with chronic cough of unknown cause.
Although coughing is an important protective reflex and a universal symptom of health, when it persists, it is the most common cause for patients to seek medical attention. The cough is triggered by the activation of the vagus afferent nerves, which terminates in the larynx, trachea, and bronchi. Numerous subtypes of vagus nerve innervate the airways and lungs.
Upper respiratory tract infections (URTIs) or colds are currently the most common cause of cough. Physicians have found that in a significant number of patients, coughing is resistant to specific therapies, even when an underlying cause has been identified. Regardless of whether the cough is acute or chronic; It is associated with significant impairments in quality of life related to health. Sleep disturbances, nausea, chest pain, and lethargy are common, and patients with chronic cough often experience social embarrassment, urinary incontinence, and malaise. When coughing causes absenteeism from work and school and loss of productivity, it creates significant economic costs for the sufferer and the community.
Common cough medicines include H1 receptor antagonists, dextromethorphan, opioids such as codeine and morphine, local anesthetics, and herbal remedies. The clinical need for non-specific cough medicines is determined by the widespread sale of these drugs: $ 3 billion a year in the United States, which has increased in recent years. Many people buy herbal and non-herbal over-the-counter (OTC) cough medicines for themselves or their children.
Results of pharmacological and clinical studies:
Various trials have confirmed the effect of thyme on productive cough. In a randomized double-blind study, 60 patients with whooping cough received thyme or bromhexine syrup for a period of 5 days. No significant difference was observed between the two groups, and both groups received the same benefit from taking the drug, according to the patient’s symptoms. Significant non-statistical improvement was observed in the recovery rate of non-smokers compared to smokers in both groups.
Thyme essential oil is effective on pathogenic bacteria, especially S. aureus.
Examination of the effects of Zataria multiflora on systemic inflammation in guinea pig COPD model showed that the preventive effect of Zataria multiflora hydroanthanolic extract on all measured parameters (such as serum interleukin 8, malondialdehyde, WBC and eosinophil count) is comparable to dexamethasone or even higher.
In vitro and in vivo, rhamnogalacturonan isolated from the root of marshmallow has shown various biological effects on the cough reflex and smooth muscle responsiveness of airways induced by citric acid. It has a dose-dependent antitussive effect comparable to codeine (a drug agonist). However, in vitro and in vivo, airway smooth muscle reactivity was not significantly affected by rhamnogalacturonan, so the bronchodilator effect was not involved in cough suppression. In addition, activation of K + ATP ion channels had no effect on the mechanism of antitussive effect. The mechanism of the cough suppressant effect of rhamnogalacturone isolated from marshmallow root seems to be related to the function of 5-HT2 serotonergic receptors.
Also, in the antitussive effect of marshmallow-derived rhamnogalacturonan polysaccharide in guinea pigs, it was found that marshmallow inhibited dose-dependent cough reflex in non-susceptible piglets and simultaneously reduced the conditions of allergic inflammation induced in susceptible mice. Codine antitussive (10 mg / kg, orally) was comparable to high doses of rhamnogalacturon in similar conditions in non-susceptible animals.
Today, angiotensin-converting enzyme (ACE) inhibitors are important drugs in the treatment of hypertension, heart failure, and some nephropathic diseases, but one of the most common side effects of these drugs is a dry, itchy, often irritating cough that may About 15 to 39% of these patients get it and it leads to discontinuation of treatment. In a placebo-controlled double-blind clinical trial, 60 patients with hypertension and cough caused by ACE inhibitors were treated with marshmallow or placebo for 4 weeks. The results showed that marshmallow has important effects in reducing and treating cough caused by ACE inhibitors.
Among non-antibiotic cough medicines, herbal medicines containing the extract of love leaves with the scientific name of Hedera helix are very popular. In a systematic review to evaluate the efficacy and tolerability of love consumption in acute upper respiratory tract (URTI) infections, the results of 10 clinical studies (love alone or love with thyme) showed that love leaf extract is effective in reducing URTI symptoms and may combine love and Thyme has a greater effect.
The dried extract of love leaves has been recorded as a laxative in patients with respiratory diseases associated with sputum cough. In addition to the secretolytic properties, the relieving effects of bronchospasm are also mentioned. In a double-blind, randomized, placebo-controlled clinical trial, 30 children aged 11-9 years with partial allergic asthma or mild persistent uncontrolled asthma were studied despite prolonged treatment with 400 μg budesonide equivalent. After a four-week run-in period, patients used dry love leaf extract with an inhaled corticosteroid or placebo. There was a wash-out step before changing the type of treatment. Lung function, exhaled nitric oxide (FeNO) levels, dense exhaled air pH and quality of life were analyzed after each treatment period.
There was a significant improvement in MEF75-25, MEF25 and vital capacity (VC) after treatment with dry leaf extract extract, but no such improvement after placebo treatment. This study showed that children with mild uncontrolled asthma, despite regular treatment with inhaled corticosteroids, may benefit from adjunctive therapy with dry love leaves.
In a randomized double-blind clinical trial, 188 patients with acute cough received Cafnolix syrup containing Zataria multiflora, Aloe vera and love (93 patients) or Dextromethorphan syrup (95 patients) at a dose of 5 ml every 8 hours for 4 days. Visits at the beginning and end of the study were conducted in person and at intervals of 24 and 48 hours after the start of treatment by telephone and the findings were recorded in a questionnaire. The severity of cough was determined by the patient based on VAS scoring on a ruler from zero to 10 (number zero: no cough and number 10: debilitating cough). In each study, the level of recovery was assessed as complete recovery (complete cessation of cough), partial recovery (patient satisfaction with cough reduction or reduction in duration of cough to half) or no improvement (no change in cough severity). According to the results of this study; Cough intensity scores at the beginning of the study, 24, 48 and 96 hours after treatment in the dextromethorphan group were 5.53, 4.78, 3.07 and 1.25, respectively, and in the caphenolix group were 6.04, 4.57 and 2, respectively. It was 53 and 0.54, which showed a statistically significant decrease in the severity of cough in both groups at all stages. (p ‹0.001) Also after 96 hours of treatment, the rate of complete recovery was 39.4% in the dextromethorphan group and 61.7% in the caphenolix group and the difference between the two groups was statistically significant (p = 0.008). The researchers concluded that the syrup containing thyme, marshmallow and love with good effectiveness and more than dextromethorphan can be a good alternative to treat cough.
Barij Essential Pharmaceutical Company is a manufacturer of herbal medicines and the first pharmaceutical knowledge-based company in the country. This company was established in 1992 with the aim of improving and promoting the health of the community.
Factory: Kashan Mashhad Ardehal | Phone: 4002 (086)
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