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Aloe vera gel has potent immunomodulatory effects during which it suppresses the production of inflammatory cytokines induced by lipopolysaccharide and the expression of NLRP3 inflammation in human macrophages. in ﬂ ammasome is a large intracellular complex consisting of several proteins that play an essential role in innate immunity. Aloe vera is able to inhibit the inflammatory process following heat damage, which is characterized by decreased adhesion of proinflammatory leukocytes and cytokines. The use of aloe vera significantly increases the phagocytic and proliferative activity of the reticuloendothelial system. Aloe vera directly inhibits the cyclooxygenase pathway and reduces the production of prostaglandin E2, which plays an important role in inflammation.

Aloe vera also contains anthraquinones (aloin) and chromone (aloesin) in the inner gel portion and has strong anti-inflammatory effects, as shown in mouse macrophages. A clinical study has shown that 2% aloe vera gel is effective in reducing the pain score and size of recurrent mouth sores.

In evaluating the effects of vitamin C and aloe vera juice on the activity of natural killer cells (NK); In vitro from the provided NK, blood samples from 12 healthy volunteers were used. The results showed that both substances increase the cytotoxicity of NK against K562 cancer cell line. In the in vivo study, 15 healthy volunteers took a daily supplement containing 1 gram of vitamin C and 50 ml of aloe vera juice for 45 consecutive days. The results showed that compared to the period before supplementation, NK cytotoxicity increased significantly (p <0.05). The results of both studies showed that vitamin C and aloe vera juice increase the cytotoxicity of NK and are able to strengthen the immune system.

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In a study in male rats, oral administration of aloe vera extract at a daily dose of 300 mg / kg body weight for 21 days before and 7 days after gamma radiation had beneficial protective effects against oxidative stress caused by radiation. .

Although the mechanisms of action of aloe vera gel are not known, in vivo aloe vera gel and its compounds modify the inhibition of UV-induced immunity. Also in vitro, some components of aloe and its whole gel have antioxidant effects. Aseman, which is one of the main components of aloe vera gel, has immune stimulant effects.

Alloctin A stimulates the production of lymphocytes by stimulating T cells. The skies stimulate the antigenic and mitogenic responses of human lymphocytes. By injecting cereals into mice or adding them to mouse macrophage culture medium, the production of different types of immunologically active interleukins is stimulated. Aloe vera gel has been added to dietary supplements used in clinical trials of AIDS patients. A polysaccharide component of aloe vera gel called mannan aseman acetyl has been used to treat AIDS patients and has reduced patients’ symptoms by 717%, possibly due to immune stimulation, although some patients have not responded. In cultured human lymphocyte cultures infected with HIV-1, the skies increased the ability of cells to survive and reduced the viral load, possibly due to inhibition of glycosylation of viral glycoproteins.

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Other effects include inhibition of virus-induced cell fusion and inhibition of virus release. Sky with azidothymidine has a synergistic effect and causes a lower dose of this drug. Aloe-emodin destroys the coating of viruses such as herpes and influenza A and has no toxic effect on host cells.

Aloe vera polysaccharides enhance innate immune activity and suppress oxidative damage in animals with oral ulcers.

Based on the results of recent studies; Aloe vera significantly reduces the production of cytokines IL-8, TNF, IL-6 and IL-1 in a dose-dependent manner. Aloe vera also inhibits the expression of pro-IL-1, Nlrp3, caspase-1, and the P2X7 receptor in lipopolysaccharide-induced primary macrophages. The researchers concluded that aloe vera is a new therapeutic approach to regulating the responses induced by inflammation.

The release of interleukin I, interleukin 6, α -TNF, δ-INF from macrophages is induced in a dose-dependent manner.

Sky alone or in combination with the antiviral drugs azidothymidine and acyclovir prevent the spread of the AIDS virus and herpes.

Aloe vera inactivates influenza viruses, Varicella zoster and Pseudorabies. Anthraquinones extracted from aloe also kill coated viruses.

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