Constipation is a dysfunction in the intestines, which manifests itself as reduction in the usual motility of the intestines, dry stool, forced defecation, difficult defecation, defecation only in long intervals, or incomplete defecation. Constipation is a prevalent condition; its prevalence has been reported as 2-28% in adults. Although many patients self-treat with OTC drugs or home remedies, constipation takes up a high number of doctor visits, and inflicts much cost.(1) Apart from costs, avoiding the management of constipation results in a reduction in life quality and aggravation of anorectal disorders like hemorrhoids. Apart from dietary and behavioral treatments, a variety of medications are used: bulk-forming laxatives (made from natural resources, like agar, psyllium and herbal gums, or synthetic resources, like cellulose), emollient laxatives, lubricant laxatives, stimulant laxatives (like aloe vera, cascara, senna compounds, bisacodyl, caster oil), saline laxatives (containing ions like magnesium, sulfate, citrate and phosphate), and osmotic laxatives (made from poly ethylene glycol).
Caster oil increases intestinal motility by stimulating the smooth muscles of the intestines. To most patients, caster oil has an unpleasant taste. Therefore, its formulation into soft capsule increases patient compliance.(2)
In the formulation of Castorex Barij Soft Capsule, fennel essential oil is also used, which, due to its stimulant effects on intestinal peristaltic movements, has laxative effects,(3,4) and helps increase the efficacy of caster oil. In addition, it has spasmolytic effects in higher doses.(4)