Modern society today is facing an epidemic of overweight and obesity that affects almost a third of the world's population and continues to increase. Body mass index (BMI) is usually a simple index for classifying overweight and obesity in adults and is obtained by dividing the number of weight in kilograms by the square of the number of height in meters (kg / m2). According to the World Health Organization (WHO), BMI ≥ 25 is overweight and BMI ≥ 30 is obesity.

The main cause of obesity and overweight is an imbalance between calories received and calories consumed. Obesity leads to dangerous consequences such as cardiovascular disease, diabetes, musculoskeletal disorders especially osteoarthritis and some cancers such as endometrial, breast and colon cancers.

There are many pharmacological and non-pharmacological treatments for weight loss and obesity treatment, none of which have a definite effect. According to research, in order to create weight loss or stabilize it, as well as improve the body's physique and increase lean muscle mass, citrus-derived compounds can be used orally in humans. These compounds can also be used to reduce or control weight with or without calorie restriction. Impact mechanism; Increased thermogenesis (speeding up metabolism and facilitating lipolysis) as well as suppression of hunger have been reported to be more pronounced, especially in high doses and in those whose active ingredients readily cross the blood-brain barrier.

To evaluate the effects of lemon essential oil on weight loss in mice alone or simultaneously with the administration of ketotifen (an antihistamine that causes weight gain); Over a period of 45 days, compared with the control group, rats receiving ketotifen showed an increase in food intake and body weight. Mice treated with lemon essential oil; Weight loss and food intake were reported to be due to anorexia. Interestingly, co-administration of lemon essential oil with ketotifen significantly suppressed weight gain and weight loss in mice. According to the information obtained in this study, lemon essential oil plays an important role in weight loss and can be useful in the treatment of obesity caused by drugs and related diseases.

In order to evaluate the effects of daily consumption of cumin and lemon soft capsule combination on weight loss and metabolic status in overweight people, during an uninformed randomized controlled clinical trial on 74 overweight people in the age range of 15-65 years, after two During the Run-in period, subjects were randomly assigned to take a 75 mg dose of cumin and lemon soft capsules (n = 24) or a 25 mg dose of cumin and lemon soft capsules (n = 24) or a placebo (n = 24). Subjects were asked to take soft capsules and placebo twice a day for 8 weeks, during lunch and dinner (soft capsules of lemon half an hour before meals and soft capsules of cumin after meals). Weight changes and BMI at the end of the intervention were recorded in three groups. Biochemical measurements including metabolic profiles, total plasma antioxidant capacity (TAC) and total glutathione (GSH) were performed before and after the intervention.

Based on the results of this study, at the end of the study in people receiving a dose of 75 mg soft cumin and lemon capsules, 25 mg soft cumin and lemon capsules and placebo weight changes (respectively 1.7 / 2.1, 1.5 ± 1.2) /- and 1.3 ± 0.2 kg) and changes in BMI (-0.8 ۶ 0.6, -0.5 و 0.5 and 0.1 ۵ 0.1 kg / m2) were observed, respectively. The changes in both treatment groups compared to the placebo group were significant but close to each other. In addition, 75 mg dose of pearl lemon and cumin resulted in a significant reduction in fasting blood sugar (-20.25 / 25 vs. -7.8 ۶ 16.8 and + 4.6 + 14.3 mg / dL). , P <0.001), significant increase in insulin sensitivity (+ 0.02 + 0.02 vs. + 0.01 + and -0.01, 0.01, P = 0.008), decrease Significant triglyceride levels (-5.5 ± 1/14- vs. + 36.9 ۸ 36.8 and + 25.6 + 1/25 mg / dL, P = 0.03), total cholesterol (28.4 ۶ 6/6) / 18- vs. 28.5 + + 6.6 and mg / dL 24.8 ۱ -0.1, P = 0.004) and LDL cholesterol (11.8 20 20.7 vs. 23.2%) + 6.5 and 2-9 ± 20.4 mg / dL, P = 0.01) were compared with pearl lemon, cumin and placebo in the 25 mg dose groups. The researchers concluded that a total dose of 25 mg of pearl lemon and cumin for 8 weeks in overweight people had beneficial effects on weight loss, and a dose of 75 mg in addition to weight loss in overweight people improved metabolic profiles compared to Involved with the control group.