In a double-blind randomized clinical trial to compare the effect of herbal medicine containing cumin, sedative, aloe vera and marjoram with placebo along with diet for weight loss on some biochemical parameters and anthropometric indices in obese people with BMI between 30 and 40 in the age range of 20 For 50 years, 68 patients were randomly divided into two groups of 34 patients. In the drug group, patients received 3 grams of drug powder (in capsules in three divided doses) daily, and in the placebo group, 3 grams of starch (in capsules in three divided doses) were administered for 8 weeks. In this study, patients’ weight, BMI index and biochemical parameters were measured at the beginning and end of the study. The results of the study showed that in addition to a significant reduction in weight and body mass in the drug group compared to placebo, the use of slimming drug reduced the inflammatory mediators TNF-α and hs-CRP in the drug group. Possible mechanism of the drug, reduction of triglyceride uptake by adipocytes and reduction of adipose deposition through decreased enzyme activity of lipoprotein lipase and acetylcholine desachurase, decreased pre-adipocyte differentiation by decreased expression of transcription factors regulating adipogenesis, such as adipogenesis and PP size. Increased enzyme activity inhibits carnitine palmitoyl transferase. This study also showed that taking this product for 8 weeks did not cause any side effects.