1- Medical literature and articles
Diarrheal diseases are still one of the main causes of debilitation and death throughout the world. The first measure for treatment of diarrhea is to supply water and electrolytes and other measures serve to alleviate symptoms such as nausea, vomiting and cramps and to shorten the course of the disease. By surveying the biological functions of phytoconstituents extracted from plants with antispasmodic mechanisms, delay in intestinal transit, inhibition of intestinal motility, stimulation of water absorption or reduction of electrolyte secretion, some studies have approved the use of antidiarrheal plants.(1) The terpenes and terpenoids present in essential oil of summer savory have antispasmodic and antimicrobial properties, therefore it can also be used in the case of microbial diarrheas.
2- Pharmacological Studies
In comparison of the antispasmodic properties of essential oil of summer savory with that of atropine and dicyclomine against spasms induced by KCl and acetyl choline in isolated rat ileum, it was demonstrated that summer savory essential oil has relaxant properties in smooth muscles of the ileum. Also, summer savory essential oil inhibits diarrhea induced by caster oil in mice.(2)
3- Clinical Trials
In a controlled, double-blind clinical trial, 71 patients with type I diarrhea in the range of 10-65 years of age were randomly divided into two groups of Lumex Oral Drop (39 patients) or placebo (32 patients) and were monitored over a period of 3 days. The administered dose was 20 drops three times a day and patients were followed up after 24, 48 and 72 hours after the initial visit. The data was statistically analyzed using SPSS. Based on the results of this study, the mean time needed for the diarrhea to stop was 17.3 hours for the group receiving Lumex Oral Drop and was significant in comparison to the group receiving placebo (35.3 hours) (p=0.013). After 48 hours, the number of times of diarrhea was lower in the group receiving Lumex Oral Drop, which was statistically significant in comparison to the placebo group (p=0.003). Also, 24 hours after the beginning of the treatment, the prevalence of cramps was 15.4% in those taking Lumex Oral Drop and 40.6% in the placebo group (p=0.16). The results of this study manifested the value of Lumex Oral Drop for alleviation of symptoms of diarrhea in relation to the placebo.(3) With regard to the studies carried out, Lumex Oral Drop is a fast acting adjuvant antidiarrheal treatment with no adverse effects.