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Due to its valuable therapeutic effects, aloe vera has been used for thousands of years and its applications have been recorded in the ancient civilizations of India, Egypt, Greece, Rome and China, so that in Egypt it is called an immortal plant and in China it is called a youth elixir. Aloe vera to strengthen, maintain health and therapeutic purposes including wound healing, burn healing, reducing frostbite damage, protecting the skin from X-rays, lung cancer, digestive problems, increasing HDL and lowering LDL, lowering blood sugar in diabetics, It has been used to combat Acquired Immune Deficiency Syndrome (AIDS), allergies and to improve the immune system. Aloe vera gel contains more than 200 biologically active ingredients and there is clinically proven evidence for aloe vera products to lower LDL, increase HDL, lower blood sugar, improve genital herpes and psoriasis.

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Although the mechanisms of action of aloe vera gel are not known, in vivo aloe vera gel and its compounds modify the inhibition of UV-induced immunity. Also in vitro, some components of aloe and its total gel had antioxidant effects. Aseman, which is one of the main components of aloe vera gel, has immune stimulant effects.
Alloctin A stimulates the production of lymphocytes by stimulating T cells. The skies stimulate the antigenic and mitogenic responses of human lymphocytes. By injecting cereals into mice or adding them to mouse macrophage culture medium, the production of different types of immunologically active interleukins is stimulated. Aloe vera gel has been added to dietary supplements used in clinical trials of AIDS patients.

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A polysaccharide component of aloe vera gel called mannan sky acetyl has been used to treat AIDS patients and has reduced patients’ symptoms by 717%, possibly due to immune stimulation, although some patients have not responded. In cultured human lymphocyte cultures infected with HIV-1, the skies increased the ability of cells to survive and reduced the viral load, possibly due to inhibition of glycosylation of viral glycoproteins. Other effects include inhibition of virus-induced cell fusion and inhibition of virus release. Sky with azidothymidine has a synergistic effect and causes a lower dose of this drug. Aloe-emodin destroys the coating of viruses such as herpes and influenza A and has no toxic effect on host cells.

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Aloe vera polysaccharides enhance innate immune activity and suppress oxidative damage in animals with oral ulcers. Based on the results of recent studies; Aloe vera significantly reduces the production of cytokines IL-8, TNF, IL-6 and IL-1 in a dose-dependent manner. Aloe vera also inhibits the expression of pro-IL-1, Nlrp3, caspase-1, and the P2X7 receptor in lipopolysaccharide-induced primary macrophages. The researchers concluded that aloe vera is a new therapeutic approach to regulate responses elicited by in ﬂ ammasome (a large intracellular complex of multiple proteins that play a key role in innate immunity). The release of interleukin, interleukin 6, α -TNF, δ-INF from macrophages is induced in a dose-dependent manner. Sky alone or in combination with the antiviral drugs azidothymidine and acyclovir prevent the spread of the AIDS virus and herpes. Aloe vera inactivates influenza viruses, Varicella zoster and Pseudorabies. Anthraquinones extracted from aloe also kill coated viruses.

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