Compared to healthy people, patients with depression report a higher rate of sexual dysfunction.
There are several treatment options for depression, including psychotherapy, physical activity, electroconvulsive therapy (ECT), and psychopharmacotherapy (antidepressants).
Several studies have shown that the effectiveness of antidepressants is limited and the therapeutic effect is observed in 70% of patients with depression, and 4 weeks after starting treatment, only 50% of patients adhere to continued treatment.
Probably due to a delay of two weeks or more to start the effect and various side effects such as weight gain, dry mouth and sexual dysfunction.
Sexual dysfunction due to the use of selective serotonin reuptake inhibitors (SSRIs) (such as citalopram, fluoxetine, fluvoxamine, and sertraline);
With a prevalence of 25.8 to 80.3%, it is one of the most worrying and destructive side effects of this group of antidepressants.
In fact, these drugs have a negative effect on one or all stages of the sexual cycle and reduce libido, arousal and erectile dysfunction;
They are more likely to be erectile dysfunction and delay or lack of orgasm, and a significant disadvantage of drug therapy for major depression with selective serotonin reuptake inhibitors is the role of these drugs in sexual dysfunction.
And the recommended treatments for SSRI-induced sexual dysfunction are drugs such as sildenafil, tadalafil, mianserin, and bupropion, which have not been approved by the US Food and Drug Administration.
In order to evaluate the effect of rose essential oil in male patients with major depression treated with SSRI, in an uninformed double-blind clinical trial, 68 patients were randomly assigned to the rose essential oil or placebo group.
In addition to taking SSRIs used for 2 weeks, 2 ml of rose product made by Barijas Essence Company containing 17 mg of citronellol per day
(Standardized based on at least 5.8 mg of citronellol per ml of product) or 2 ml of an aqueous solution with a rose-like odor.
Patients reported depressive symptoms and sexual function 4 weeks and 8 weeks later (end of the study).

At the end of the study, the findings were analyzed on 60 people (30 people in each group). According to the results of this study, over time, sexual dysfunction in the rose essential oil group improved more than placebo.
Improvement in sexual function was observed in the rose essential oil group from week 4 to week 8. Depressive symptoms of patients in both groups decreased over time, but in the rose essential oil group was more than placebo.
This study showed that consumption of rose essential oil eliminates sexual dysfunction in male patients with major depressive disorder and SSRI-induced sexual dysfunction.
In addition, as the sexual dysfunction improves, so do the symptoms of depression.
Also, in a double-blind clinical trial to evaluate the effect of rose essential oil in female patients with major depression treated with SSRI, 61 patients were randomly assigned to the rose essential oil or placebo group.
In addition to taking SSRIs used for 2 weeks, 2 ml of rose product made by Barijasans Company containing 17 mg of citronellol per day
(Standardized based on at least 5.8 mg of citronellol per ml of product) or 2 ml of an aqueous solution with a rose-like odor.
At the beginning of the study, 4 weeks later and at the end of the study, patients completed their Depression and Sexual Function Questionnaire. At the end of the study, the findings were analyzed on 50 people (25 people in each group).
According to the results of this study; Increased libido, orgasm and sexual satisfaction occurred over time.
Patients in the rose group reported a decrease in pain during intercourse, and the overall score of sexual function in the rose group increased compared to placebo.
The researchers concluded that although in male patients with SSRI-induced depression and sexual dysfunction, adjuvant therapy with rose essential oil improves sexual function.
Findings about rose essential oil in female patients with major depression with SSRI-induced sexual dysfunction indicate less effect of this product on improving sexual function.

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