Clinical trials have shown the benefits of evening primrose oil (EPO), which is a source of GLA, in cases such as diabetic neuropathy, hypertension, breast pain, premenstrual syndrome, menopausal hot flashes, atopic dermatitis, osteoporosis and dementia. . Evening primrose oil has anti-inflammatory effects; Correction of omega-6 essential fatty acid deficiency; Improving the synthesis of vasodilators; Correction of nerve blood flow and defects in nerve conduction velocity in diabetic patients. GLA is one of the essential fatty acids that the body is unable to produce and like vitamins it must reach the body through food and supplements. Part of the beneficial properties of this product is due to the increased production of prostaglandin E1, which has anti-inflammatory effects. The following are the results of several clinical trials.
During the 17 years to 1992 at the Cardiff Mastalgia Clinic, patients with periodic pain and 90 patients with non-periodic breast pain; They received various drug treatments in clinical trials. In patients who responded to treatment, danazol was the most effective drug (approximately 70%) and bromocriptine and evening primrose oil had the same effect (approximately 45%). Patients receiving evening primrose oil also reported fewer side effects.
In parallel, randomized, placebo-controlled, placebo-controlled trials in 7 centers in the UK and Finland, 111 patients with mild diabetic neuropathy (480 mg GLA per day) received placebo for 1 year and were tested by standard case studies. Were evaluated. In the group therapy, a significant favorable change was observed in 13 of the 16 parameters studied, indicating an obvious beneficial effect on the course of mild diabetic neuropathy. Gender, age, type of diabetes, age of onset or course of diabetes had no significant effect on outcome. However, treatment was more effective in patients with relatively well-controlled diabetes. Patients were able to continue the trial for another 12 months, and all those who participated in the course were given GLAs (indefinitely) and continued to recover during the course.
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